The generic name for prednisone is prednisone acetate, and the duration of taking prednisone acetate to lower urinary protein depends largely on whether the disease is hormone-sensitive or not. If it is hormone-sensitive about 8 to 12 weeks, if it is hormone-dependent or hormone-resistant, the duration of medication can not be determined. Prednisone acetate belongs to the glucocorticoid class of drugs, through the inhibition of immune-inflammatory response, inhibit aldosterone and antidiuretic hormone secretion, affect the glomerular basement membrane permeability and other comprehensive effects to play its diuretic, eliminating the efficacy of urinary protein. If the disease is sensitive to hormone therapy, such as microscopic lesion nephropathy, mild tethered proliferative glomerulonephritis, etc., usually the treatment for 8 to 12 weeks can relieve the condition and reduce urinary protein. If the disease is not sensitive to hormone therapy, such as focal segmental glomerulosclerosis, membranous nephropathy, lupus nephritis, etc., it will take longer, and may even be ineffective for conventional hormone therapy, and need to be synergized with cytotoxic medications (e.g., cyclophosphamide, phenylbutyrate nitrogen mustard, etc.) or other drugs. The drug is contraindicated in people who are allergic to adrenocorticotropic hormones, have hypertension, glaucoma, thrombosis, gastric and duodenal ulcers and other diseases. If patients need to apply hormone drugs, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects.