Chronic inflammation of gastric sinus mucosa with enterorrhea can generally be cured, and the treatments include general treatment, medication such as omeprazole, clarithromycin, bismuth potassium citrate, and surgical treatment. 1. General treatment: patients should try to remove possible causative factors, such as developing good living habits, dietary habits, quitting smoking and drinking, and avoiding drugs such as ibuprofen that may damage the gastric mucosa. 2. Medication: If the patient has Helicobacter pylori infection, it is recommended to take metronidazole, clarithromycin, bismuth potassium citrate, omeprazole and other medicines under the guidance of the doctor for treatment; abdominal distension caused by lesions is recommended to use mosapride, pepsin combination and other medicines under the guidance of the doctor for treatment. 3. Surgical treatment: If it is a serious intestinal metaplasia, it is recommended to consult a doctor in time for surgical treatment if necessary. In conclusion, chronic inflammation of the gastric sinus mucosa with intestinal chemosis can be cured in general, and patients should follow the doctor’s instructions in order to recover as soon as possible.