Tinidazole has a relieving effect on toothache of bacterial infection origin. Toothache can be caused by a variety of reasons, the common is bacterial infection of dental hard tissues of the dental nerve inflammation, mainly anaerobic bacteria, anaerobic bacteria are more sensitive to tinidazole, so caries source of toothache oral tinidazole can relieve the pain. Oral medication for toothache is only an adjunctive treatment, and root canal treatment of the tooth is required. For toothache caused by the trigeminal nerve, or wisdom tooth pericoronitis source of toothache, tinidazole effect is not obvious, need to carry out trigeminal nerve sealing or wisdom tooth pericoronary rinsing medicine to relieve the pain. Therefore, tinidazole can relieve toothache caused by anaerobic infection, the specific should be used under the guidance of a physician, it is recommended to go to the dentist for dental treatment.