Monkeypox is not smallpox, the two mainly in the pathogenesis, infectiousness and lethality and clinical manifestations of the difference. The two are different in terms of the cause of the disease, the infectiousness of the monkeypox virus, and the death rate of smallpox virus. 3, clinical manifestations: although the clinical manifestations of the two diseases are similar, the early stage can appear the performance of rising body temperature, facial, limbs, trunk, genitalia and oral mucosa, tongue mucosa and other parts of the rash will appear, but monkeypox will generally appear before the rash unilateral or bilateral lymph node enlargement, especially in the cervical lymph nodes, inguinal lymph nodes.