Vitiligo is often associated with autoimmune diseases, and there are also a variety of antibodies against melanocytes in the patient’s body, so it can be seen that one of the pathogenesis of vitiligo is related to immunity, so for progressive and generalized leukoplakia, especially for those with rapid development of leukoplakia under stress and concomitant immune diseases, systemic glucocorticoid therapy can stop the rapid development of progressive disease, because of its powerful inhibitory immune and inflammatory The systemic glucocorticosteroid therapy can stop the rapid progression of progressive disease due to its powerful immune and inflammatory suppressive effects. Dermatologic hormones include both internal and external use, basically, the name of the drug is with the word “pine”, because corticosteroids in English is corticoid, which translates to “cortisone”, such as hydrocortisone, dexamethasone, prednisone The topical medications such as hydrocortisone, dexamethasone, prednisone, etc., and topical medications such as Eloson (mometasone furoate cream), etc., some of them may not be very clear because we often call them by their trade names directly, like the dermatophylline that often appears in advertisements, the scientific name is compound dexamethasone acetate cream, which is also a hormonal topical medication, and the new Stipend (halomethasone/triclosan cream), etc. There is a solution that often escapes the strict scrutiny of the people. The actual fact is that you can find a lot of people who are not able to get a good deal on a lot of things. For the progressive vitiligo, such as the limited type, can be local treatment, such as topical glucocorticoids (referred to as hormones) or calcium-regulated neurophosphatase inhibitors (tacrolimus, pimecrolimus), etc.; local phototherapy optional narrow-spectrum medium-wave ultraviolet (NB-UVB), 308 nm excimer laser and excimer light, high-energy ultraviolet light, etc. In addition to local treatment, Chinese herbal medicine, immunomodulators and systemic glucocorticoid therapy can be added for patients with progressive epidemic, pancytopenia and acromegaly. Glucocorticoids are currently the most effective therapeutic drugs to control the progressive stage of pancytopenia and epidermolysis bullosa, which can inhibit the immune response of autoantibodies to melanocyte damage, control the development of the disease and promote the recovery of pigmentation. However, hormone medicine is also a typical “double-edged sword”, that is, at the same time also has extremely serious, even fatal side effects. For example, large doses of hormones can cause metabolic disorders such as adrenocorticolism, peptic ulcers, osteoporosis, secondary infections, adrenocortical insufficiency, and psychiatric abnormalities. Therefore, caution is needed when using them, especially for children. But parents should not be overly anxious, the 2009 version of the “Vitiligo Treatment Consensus Revision” has made the following special guidance on the use of drugs for children with vitiligo: it is proposed that for children <2 years old with limited white spots can be treated with intermittent topical medium-acting hormones, and children >2 years old can be treated with topical medium- or strong-acting hormones. The most clinically challenging rapidly progressive stage of childhood vitiligo is recommended to be treated with small doses of oral hormones, and oral prednisone 5-10mg/d for 2-3 weeks is recommended. If necessary, the treatment can be repeated once more after 4-6 weeks. The above medication regimens are discussed repeatedly to achieve the best results and to minimize side effects. In addition, when taking hormones, doctors usually advise patients to take them at eight o’clock in the morning after meals, because the side effects of hormones are minimal at this time and taking them after meals can reduce the irritation to the gastric mucosa. Therefore, patients or their family members should cooperate with the doctor’s treatment and trust each other.