Chinese and Western medicine have their own strengths and weaknesses in treating diabetes. Although Western medicine alone has side effects such as easy drug resistance, secondary failure, gastric discomfort and skin rash, it is readily accepted by patients because of its rapid glucose-lowering effect and ease of administration or use. Although Chinese medicine alone has no adverse effects and can control clinical symptoms and complications, the effect of lowering sugar is slow and less strong. Only the combination of Chinese and Western medicine in the treatment of diabetes can improve clinical symptoms and prevent complications, but also avoid the adverse reactions and secondary failure of drugs. The current combination of Chinese and Western medicine in the treatment of diabetes can be in three areas of effort. ① Find the combination of Chinese and Western medicine. The combination of Chinese medicine with small doses of western hypoglycemic drugs is a feasible way to treat diabetes. It is worth noting that even if small doses of western hypoglycemic drugs are used in combination, it is necessary to skillfully combine Chinese medical diagnosis and western medical diagnosis according to the dialectical materialist viewpoint, and select the corresponding hypoglycemic western drugs according to the fluctuation of blood glucose under the comprehensive consideration of the patient’s age, height, weight, work nature and other specific conditions. ②According to the principle of identification in Chinese medicine, the pharmacological research results of the predecessors are flexibly absorbed. Pharmacological research has significant hypoglycemic effect of traditional Chinese medicine, such as ginseng, astragalus, yellow essence, yam, wolfberry, groundnut, poria, Xianling spleen, shamrock, angelica, etc.; with the effect of clearing and detoxifying, regulating qi and activating blood atractylodes, cornus, lychee kernel, five times the seed, salvia, mulberry leaf, mulberry bark, Zhi Mu, guanxi, etc.. The clinical selection of drugs on the basis of evidence-based selection can really improve the efficacy, but we should pay attention to the evidence-based selection of drugs, otherwise it will not be effective, such as Yang deficiency of the body and the injection of Zhi Mu, Cang Zhu and so on is not appropriate. ③ Develop special prescriptions and medicines according to the essence of the disease mechanism. Seize the main pathological characteristics of a certain type of diabetes or a certain period of time, determine the principles of treatment, and develop special prescriptions and medicines for research. For example, for the main line of the pathological mechanism of diabetes mellitus Qi and Yin deficiency, we have formulated the Qiringhuang hypoglycemic tablets with the effect of benefiting Qi and nourishing Yin, activating blood circulation and resolving blood stasis, which are used for clinical effect according to the characteristics of the pathological mechanism of diabetes mellitus Qi and Yin deficiency with blood stasis. The pharmacological research has confirmed that all of them have significant efficacy in lowering blood sugar, blood pressure and blood lipids, providing effective prescriptions for the prevention and treatment of diabetes and its complications.