Glioma grade 4, also known as glioblastoma, is one of the most malignant brain tumors, the tumor will definitely recur after surgery, because glioma is a malignant tumor, the tumor and the surrounding brain tissue has no obvious boundaries, infiltrative growth, the tumor cells will infiltrate into the crevices of the brain tissue, the surgery, even under the microscope, there is no way to do a complete resection of the tumor, the tumor cells will continue to grow after the operation, so it will certainly be Recurrence. Moreover, the malignancy of glioma grade 4 is very high, and the recurrence is early after surgery, it can be seen in 6-12 months after surgery, the prognosis is very poor, even if surgery and radiotherapy are taken, the average survival period is only about 12-14 months, and it is necessary to carry out postoperative radiotherapy to slow down the recurrence time of the tumor, and to prolong the patient’s survival period.