Honeycomb holes on the soles of the feet need to be treated according to their specific causes, such as eczema, fossa keratolysis, fungal infections, etc. After a clear diagnosis, topical glucocorticosteroids, antihistamines, antibiotics and other medications should be chosen for treatment. 1. Eczema: Eczema can cause honeycomb holes on the soles of the feet, and the treatment is mainly based on topical medications, such as Denadyl cream, mometasone furoate cream and other glucocorticoid medications, and if accompanied by itching can be combined with antihistamines, such as loratadine, and other oral medications. 2. Fossa keratolysis: Fossa keratolysis can cause honeycomb holes on the soles of the feet, and can be treated with topical antibiotics, such as mupirocin ointment and erythromycin ointment. 3. Fungal infections: fungal infections not only cause honeycomb holes on the soles of the feet, accompanied by localized flaking, treatment can choose ketoconazole cream, terbinafine cream and other antifungal medication, and at the same time pay attention to skin hygiene and sanitation to avoid cross-infection. The causes of honeycomb holes on the soles of the feet are different, the treatment is also different, it is recommended that the patient go to the hospital in time, follow the doctor’s instructions to use the above medication, do not ignore the symptoms, take it lightly.