There are various causes of darkening of the face, physiological such as sun exposure, and pathological such as viral hepatitis, cirrhosis, diabetes mellitus, melioidosis, etc. Oral medications include antiviral drugs, hypoglycemic drugs, vitamin preparations and so on according to the different causes of the disease. Physiological such as sun exposure, long-term late at night, etc., can be improved through sunscreen, improve the routine and other measures; pathological such as hepatitis, cirrhosis of the liver, diabetes, skin melanosis, etc. can be caused by darkening of the face, the treatment of medication is different. Darkening of the face, do not self-medication, should be as soon as possible to identify the cause of viral hepatitis, cirrhosis patients should be carried out as soon as possible antiviral, liver and other treatments, such as oral entecavir, tenofovir, etc., but also can be injected with interferon, etc.; hepatic and renal failure in order to treat the cause of the disease, supportive treatment is given priority to, the symptoms of the serious need for dialysis treatment. Diabetes and other causes of darkening of the face should be based on the cause of the cause of treatment, you can take oral hypoglycemic drugs such as metformin, etc., can also be injected insulin and other treatments. Black lesions should be in the dermatologist under the guidance of the elimination of triggers, oral vitamin C and other vitamins treatment, if necessary, symptomatic use of topical medications, such as hydroquinone cream, vinpocetine cream and so on. It is recommended to consult a doctor in time and follow the doctor’s instructions.