How to choose antihypertensive drugs for hypertension patients? With the improvement of people’s living standards, the prevalence of hypertension is increasing year by year, and according to the survey, the number of hypertension patients in the country has exceeded 200 million. In the face of so many kinds of drugs, how should hypertension patients choose? Generally speaking, the criteria of the ideal antihypertensive drugs are: ① efficacy, 24 hours a day, smooth and lasting antihypertensive; ② small side effects, easy to take, good compliance; ③ does not affect the patient’s quality of life, especially the quality of sexual life; ④ does not affect the metabolism of blood lipids, blood sugar, electrolytes; ⑤ can make the patient’s heart, brain, kidney and atherosclerosis and other lesions reversed. At present, long-acting antihypertensive drugs should be the best choice for patients with hypertension. Long-acting antihypertensive drugs have a 24-hour antihypertensive effect when taken only once a day, thus reducing or avoiding the harm caused by high blood pressure and frequent fluctuations; long-acting antihypertensive drugs can make hypertensive patients avoid the situation of missing medication; long-acting antihypertensive drugs have good compliance, which is convenient for long-term medication. In addition, hypertensive patients (especially the elderly) should not be too fast to reduce blood pressure to normal in 2 to 4 weeks as the best. The long-acting antihypertensive drugs have such characteristics. Although long-acting antihypertensive drugs have the effect of lowering blood pressure on the day they are taken, it generally takes about 2 weeks to achieve a stable blood pressure lowering effect, and the best blood pressure lowering effect will occur only after about a month of medication. Therefore, patients with hypertension should not rush after taking long-acting antihypertensive drugs, and should not change their medication prematurely because their blood pressure does not drop significantly after taking them. Although the side effects of long-acting antihypertensive drugs are small and have many advantages, when a patient with hypertension has a sharp rise in blood pressure within a short period of time, in order to prevent the patient from developing complications such as hypertensive crisis or heart failure or renal failure, short-acting antihypertensive drugs such as nifedipine (cardiac pain) and captopril (Kepone) can be given as needed on a temporary basis. After the patient’s blood pressure drops to the ideal level, he or she is then given a new dose of long-acting antihypertensive drugs, so that the patient’s blood pressure can remain stable around the clock. Therefore, patients with hypertension who are taking long-acting antihypertensive drugs are advised to have some short-acting antihypertensive drugs at home for emergency use. The following is a brief introduction to the main indications and side effects of the six types of commonly used antihypertensive drugs, in order to help patients with hypertension. 1, diuretics: clinically commonly used is hydrochlorothiazide and indapamide. Good efficacy and low price; mainly suitable for patients with high systolic blood pressure, obesity or concomitant cardiac insufficiency, due to the role of interference with glucose and lipid metabolism and induce hyperuricemia, so be careful with diabetes, hyperlipidemia and gout patients. 2, receptor blockers: more clinical applications are Bisoprolol, Metoprolol. It is suitable for patients with mild to moderate hypertension with a fast heart rate (80 beats/min) and moderate price. Its side effects are interference with sugar and lipid metabolism and induction of hyperuricemia, which should be contraindicated in patients with heart block and asthma. 3, calcium channel blockers: clinically used drugs are felodipine, amlodipine, nifedipine, etc.. Reliable antihypertensive and does not interfere with sugar and lipid metabolism, especially for elderly patients with hypertension with angina pectoris, diabetes mellitus and combined renal damage, the adverse effects are headache, facial flushing and ankle edema due to vasodilation. 4, angiotensin-converting enzyme inhibitors: clinically used drugs are Midapril, Enalapril and Benazepril; reliable antihypertensive and does not interfere with glucose and lipid metabolism, suitable for hypertension with left ventricular hypertrophy, cardiac insufficiency, diabetes mellitus and renal insufficiency (creatinine <3mg/L) patients, its side effects are irritating dry cough, hyperkalemia. 5, angiotensin receptor antagonists: the most clinically used are Dynavin, Coxswain and Ambrovir. Its lowering blood pressure, heart and kidney protection and angiotensin-converting enzyme inhibitors are similar, so the object of application and contraindications are also similar, the price of the drug is higher, the advantage is not to cause irritation dry cough, but also to reduce the role of blood uric acid. 6, receptor blockers: commonly used drugs are prazosin, terazosin. The drug has no effect on blood glucose metabolism and can improve lipid metabolism and difficult urination symptoms in patients with prostate enlargement, especially for hypertensive patients with prostate enlargement, whose common side effects are postural hypotension, palpitations and syncope.