Liver palms are mainly an important sign of chronic hepatitis and cirrhosis, mostly due to decreased liver function, but can also be seen in healthy people. Liver palms are flaky congestion, or red patches or spots, at the base of the thumb and little finger of the patient’s palm, and will turn pale when pressure is applied. It is usually seen in chronic hepatitis and cirrhosis. Liver palms are mainly due to liver dysfunction, estrogen metabolism is impaired to varying degrees, resulting in the accumulation of estrogen in the body, stimulating the capillary congestion, dilation, and ultimately the formation of liver palms. At the same time, liver palms can also be seen in hemochromatosis cardiomyopathy, hepatopulmonary syndrome, fulminant hepatic failure, etc., but also a small portion of the healthy population may appear liver palms. Patients need to pay more attention to rest, reasonable diet planning, and active treatment of liver disease, if necessary, patients also need to appropriate selenium supplementation. It is recommended that when patients develop liver palms, they should improve their lifestyles in a timely manner and find out the cause of the disease under the guidance of their doctors, so as to avoid delaying their condition.