Coumarin works by antagonizing vitamin K to inhibit hepatic synthesis of coagulation factors, resulting in an anticoagulant effect.
The molecular structure of coumarin is similar to that of vitamin K. Coumarin can competitively inhibit the synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X, and thus inhibit the entire coagulation process, resulting in anticoagulant effects.
Coumarins are commonly used in patients with atrial fibrillation and heart valve disease, hip surgery patients, and prevention of recurrent thromboembolic disease.
It is worth noting that excessive use of coumarins can induce bleeding, which can be countered with vitamin K and, if necessary, fresh plasma transfusion. It is contraindicated in patients with bleeding tendency, pregnancy, severe hepatic and renal insufficiency, and active peptic ulcer.
The use of the above drugs need to be under the guidance of a doctor, not blindly use their own medication.