HBsAg positive for physical examination found, multiple tests are positive, more than half a year is called chronic HBsAg positive carrier, while liver function are normal. For these groups of people in the past doctors do not think that the need for medication, regular checks of liver function can be. These unintentional discovery or physical examination found HBsAg (+) people, mostly 20-40 years old adults, they are mostly mother-to-child transmission, long-term observation of liver function are in the normal range. However, in recent years, many people go to check the hepatitis B virus nucleic acid (HBV DNA) of these HBsAg(+) people and find that many of them are high load viral copy number. Some medical personnel have incomplete explanations for this, saying that they are highly infectious and prone to develop cirrhosis and need treatment. For this reason, many hepatitis B-positive people seek medical advice everywhere. For this kind of inquiry, how to do scientific and reasonable treatment? The authors talk about two points of view: First, for this group of people still regularly check the liver function, once every six months, liver, spleen ultrasound once a year, in the process of observation found that liver function abnormalities, ALT is greater than twice the normal value or splenomegaly, platelets and leukocytes should be reduced in a timely manner to seek medical attention. Second, long-term HbsAg positive carrier for more than 5 years, with high HBV-DNA viral load, although liver function is normal, it is recommended to do biopsy and histopathological examination of the liver. Inflammatory necrosis and fibrotic changes are found to reach the antiviral standard, and standardized antiviral treatment should be carried out, which can reduce the occurrence of cirrhosis and hepatocellular carcinoma. According to the Journal of Practical Liver Diseases, Volume 15, Issue 5, 2012, Chen Hui et al. reported, “Liver histopathologic analysis of young chronic HBV carriers” that this group (20-39 years old) of chronic HBV carriers, histopathology confirms that 62.6% of the patients need antiviral treatment.