Alkaline phosphatase reference intervals vary depending on the patient’s sex and age, so it is not straightforward to determine whether alkaline phosphatase 277 U/L is above normal.
Alkaline phosphatase is a zinc-containing glycoprotein widely distributed in the human body, and the measurement of alkaline phosphatase is important for the clinical diagnosis of intrahepatic space-occupying diseases, bone disease and extrahepatic biliary obstruction, etc. The normal reference range of alkaline phosphatase for a male or female patient aged 25 years old should be 40~150 U/L. Elevation of alkaline phosphatase is commonly found in pregnant women, newborn babies, high-sugar diets, and hepatic and gallbladder diseases.
The normal reference range for alkaline phosphatase in male or female patients aged 1 to 12 years should be less than 500 U/L, while alkaline phosphatase less than 750 U/L in male patients aged 13 to 15 years is considered normal. Therefore, it is not possible to determine whether alkaline phosphatase is normal or not just from the result of the 277 U/L test.
It is recommended that patients with 277 U/L alkaline phosphatase should be referred to the gastroenterology department of a regular hospital for further consultation.