An elderly female with advanced ovarian cancer had an irregular pelvic mass of 18*12*10, which wrapped around the anterior and lateral walls of the rectum and was indistinct from the surrounding tissues. The patient suffered from painful perineal swelling and pain when walking and defecating, lumbosacral pain, sleeplessness at night and difficulty in defecating. After one interventional treatment for ovarian cancer, the patient did not experience nausea, vomiting, fatigue and other chemotherapy symptoms and tolerated it well. 1 week later, the patient’s perineal cramping pain improved and the shape of bowel movement improved. 3 weeks later, the patient was reviewed and had no pain in the lower abdomen and lumbosacral area, had smooth bowel movement, slept well, CA125 decreased by 60% compared with before and the mass shrunk. The dose of intravenous chemotherapy for larger ovarian cancer is too large for the patient to tolerate. Interventional intra-arterial injection of chemotherapeutic drugs directly into the tumor can increase the concentration of drugs by tens of times, reduce the dosage of chemotherapeutic drugs, reduce systemic toxic side effects, and combine with embolization therapy, which can significantly improve the patient’s symptoms. The patient had difficulty in defecation and perineal swelling, and was given one interventional treatment, the mass shrank 1-fold and all discomfort disappeared.