Swollen ankles and painful walking may be caused by physiological factors such as sedentary and standing for a long time, or by pathological factors such as trauma, inflammation and renal insufficiency. 1. Physiological factors: it may be related to long time poor posture, such as sedentary, standing for a long time, etc., which can affect the blood return of the lower limbs, thus leading to swelling of the ankles, walking pain symptoms. 2. Trauma: when ankle sprain, external impact can lead to ankle muscles, ligaments and other soft tissues are damaged, the patient may appear ankle swelling walking pain symptoms. 3. Inflammation: If the patient has synovitis, arthritis, degenerative osteoarthropathy and other diseases of the ankle joint, under the stimulation of inflammation, the ankle will show symptoms of swelling and walking pain. 4. Renal insufficiency: due to renal insufficiency, it can lead to water and sodium metabolism disorders in the body, inducing water and sodium retention, which often occurs in the distal parts of the limbs, and patients can have swollen ankles, accompanied by symptoms such as increased blood pressure and proteinuria. Swollen ankles and walking pain can also be seen in other causes, it is recommended that patients seek medical treatment in a timely manner, under the diagnosis and guidance of a professional doctor to carry out targeted treatment.