Atorvastatin can cause an increase in direct bilirubin. It is recommended to take the drug under the guidance of professionals and seek medical attention for any abnormalities. 1. Atorvastatin can cause abnormal liver function, jaundice, deepening of urine color, abdominal discomfort, loss of appetite, fatigue, etc. Patients with jaundice are likely to have elevated direct bilirubin. 2. In addition to the adverse reaction of liver function abnormality caused by atorvastatin, there may also be muscle damage, allergic reaction and other adverse reactions appear, manifested as unexplained muscle pain, weakness, face, throat edema and so on, pay more attention. Atorvastatin can lower LDL cholesterol and mildly raise HDL cholesterol. It is mainly used for the treatment of hypercholesterolemia, reducing the risk of myocardial infarction and stroke in coronary heart disease and other atherosclerotic cardiovascular diseases.