Parkinson’s disease is not simply a manifestation of motor symptoms such as limb tremor, stiffness, bradykinesia and fatigue, but a disease that affects all body systems and damages all organs and organs. I. Motor symptoms, which significantly reduce the quality of life of patients, are manifested as bradykinesia, resting tremor, and muscle stiffness. Balance dysfunction, once balance dysfunction occurs, it is easy to fall and cause secondary fractures and cranio-cerebral trauma. Difficulty in swallowing, choking and coughing, which may lead to lung infection, malnutrition and other complications. Digestive system symptoms, such as abdominal distension, stomach is not, constipation, etc. V. Mental symptoms, such as anxiety, depression, hallucinations, etc. Sixth, motor system symptoms, in addition to the above-mentioned motor retardation, stiffness, tremor, late stage will also appear joint deformation, muscle atrophy, joint limb contracture deformity. Circulatory system symptoms, long-term drug treatment, patients appear postural hypotension, thrombosis, etc. Eight, cognitive function changes, Parkinson’s disease in some patients combined with dementia, the late stage of communication difficulties, calculation difficulties, do not recognize family members, lost and so on. Sensory function, advanced patients can appear in many parts of the body pain, numbness. Sleep disorders, most patients in the middle and late stages will have reduced sleep, insomnia, day and night reversal, decreased sleep quality, and need medication. XI. Urinary symptoms, late stage patients have polyuria, urinary frequency, urinary urgency, urinary tract infection and other manifestations.