The difference between rabeprazole and omeprazole is mainly in terms of efficacy and adverse effects. 1. Different efficacy: the acid-suppressing effect of rabeprazole is faster, stronger and lasts longer than that of omeprazole. 2. Adverse reactions: the main adverse reactions of omeprazole are gastrointestinal reactions, such as nausea, diarrhea, constipation, epigastric pain and so on. Rash and transient elevation of bilirubin also occur. Serious adverse reactions to rabeprazole include shock, triggered hematopenia, and hemolytic anemia. Cancer such as gastric and esophageal cancer should be ruled out when taking rabeprazole for treatment. Another advantage of rabeprazole over omeprazole is that it enhances the eradication success of quadruple therapy in the dosing regimen for the removal of Helicobacter pylori, which is more effective than omeprazole. For the use of rabeprazole and omeprazole, it is recommended to visit a physician for guidance.