Different specifications of Methylprednisolone 5 tablets per day dosage is different, whether the existence of the amount of large need to be judged according to the patient’s condition and the specifications of the drug, can not be generalized. Patients with different diseases are given different doses, generally 4mg~48mg, some patients may reach 7mg/kg/day. Methylprednisolone is one of the commonly used glucocorticosteroid drugs for rheumatic diseases, skin diseases, allergic diseases, organ transplantation and edema, etc. The common specifications of the drug are 4mg/tablet and 16mg/tablet, and according to the patient’s condition, the initial dosage of Methylprednisolone can be adjusted between 4mg~48mg per day. Clinical conditions requiring treatment with higher doses include multiple sclerosis (200mg/day), cerebral edema (200-1000mg/day) and organ transplantation (up to 7mg/kg/day). Patients on prolonged treatment with methylprednisolone should be tapered off gradually if discontinuation is required. Common adverse reactions are infections, gastrointestinal perforation, and Cushing-like syndrome. Contraindicated in patients with systemic fungal infections, history of hypersensitivity to methylprednisolone tablets, methylprednisolone or any of the excipients. Take care to monitor for infection during administration. Methylprednisolone should be used under the guidance of a physician, and patients are advised to go to the relevant departments of regular hospitals for detailed consultation.