Herpes is usually caused by varicella-zoster virus infection. Herpes zoster neuralgia is one of the most severe neuropathic pains in clinical practice, manifesting as spontaneous, paroxysmal, severe slashing, stabbing, electric shock, burning-like pain at the skin where the herpes started, which can lead to painful shock in severe cases. Why does shingles in the skin cause such severe neuralgia? It is because when the skin is infected with herpes zoster, the herpes zoster travels along the nerves and damages the sensory nerve endings so that the herpes zoster virus brings about two types of damage: one, skin damage, which appears as small blisters in a typical band-like cluster on the skin. Second, it causes nerve damage, which causes various kinds of neuralgia. Depending on the timing of the pain after shingles, it can be divided into neuralgia in the acute phase and post-herpetic neuralgia. Acute phase pain occurs within a month, while those within two months are subacute. Pain that remains on the skin surface after the complete elimination of shingles is postherpetic neuralgia, which is more damaging to the patient because the pain may last for years or decades, making it very painful for the patient. Postherpetic pain treatment can be done with oral specific medications such as pregabalin, which can be done as nerve block therapy, or block therapy for the ganglion.