Cephalosporin is generally not to be sprinkled on wounds, not only the anti-infective effect is slight or ineffective, but also allergy may occur. Cephalosporin refers to cephalosporin drugs, including ceftazidime, cefamandole, cefaclor, etc. The preparations are mainly divided into intravenous drugs and oral drugs, which can be used for anti-infection treatment. Cephalosporin antibiotics are mainly absorbed into the bloodstream through the vein or gastrointestinal tract before exerting their antibacterial effects. The use of cephalosporin antibiotic preparations, which are sprinkled directly on the wound, exerts limited antibacterial effects. On the other hand, topical spraying of cephalosporin antibiotics may cause local wound irritation and pain, affecting wound repair and regeneration. Cephalosporin antibiotics may also trigger allergic reactions, which may cause anaphylaxis in severe cases. When wounds occur, it is recommended to seek medical attention and use iodophor to disinfect the wound under the direction of a physician. Medications need to be used under the guidance of a physician, and cephalosporin is contraindicated for those who are allergic to cephalosporin antibiotics.