The soles of the feet grinding up blisters can be dealt with through general treatment, medication and other ways. 1. General treatment: after the soles of the feet grinding out blisters should pay attention to rest, reduce activities, so as not to aggravate the symptoms, wear loose and comfortable shoes and socks, reduce friction, keep the affected area clean and dry, prevent infection. 2. medication: the soles of the feet grinding blisters to do a good job of local disinfection to prevent infection, you can use povidone-iodine to wipe the surface of the blisters; blisters are large, affecting the activities, you can seek medical attention after the use of sterile syringes will be blisters extracted, and then the local application of mupirocin ointment and other medications, to prevent infection. The symptoms of blisters on the soles of the feet should be serious in time to go to the hospital, under the guidance of the physician to carry out the relevant treatment, and strictly comply with the doctor’s instructions to use medication.