Melasma, also known as liver spots, is a yellowish-brown pigmentation on the face. It is mostly distributed on the cheeks in a symmetrical butterfly shape. It is mostly seen in women, but also in some patients with female reproductive system disorders, tuberculosis, cancer, chronic ethanol poisoning, liver disease, etc. Etiology Ultraviolet radiation, pregnancy, neuro-endocrine disorders, drugs (such as birth control pills, chlorpromazine, etc.), chronic diseases, etc. can cause chloasma. Clinical manifestations Melasma mostly affects young and middle-aged women, and the typical manifestation is butterfly-shaped distribution of yellowish brown or dark brown patches on the face with different sizes. No conscious symptoms. The course of the disease is variable and can last for several months or years. Generally, after the age of 50, the discoloration will gradually recede in the direction of behind the ear and jaw, and it is generally difficult to find melasma in elderly people in their 70s and 80s. Firstly, we should find the cause of the disease and deal with it accordingly; secondly, we should avoid sun exposure and make the habit of applying sunscreen; adjust emotions, avoid anxiety and keep a healthy state of mind; eat less photosensitive food; arrange sleep reasonably, etc. Thirdly, medication (such as hydroquinone cream, vitamin C, glutathione, etc.) and laser/intense pulsed light treatment (such as fourth generation intense pulsed light and Q-switched Nd-YAG laser, etc.) are available.