A syphilis rash indicates that this period is highly contagious. The appearance of a syphilis rash is considered early syphilis and is highly contagious. Syphilis is divided into early syphilis and late syphilis according to the course of the disease. Early syphilis refers to stage 1 and stage 2 syphilis, while late syphilis refers to stage 3 syphilis. Early syphilis is very contagious and late syphilis is less contagious. Typical skin manifestation of stage 1 syphilis is chancre, which starts as a small red spot on the vulva, necrotic and then forms a painless ulcer with clear boundaries; the characteristic manifestation of stage 2 syphilis is a syphilis rash, which can spread all over the body’s skin and mucous membranes, and is commonly seen as a patchy rash, maculopapular rash, and plaques, etc.; the hallmark of stage 3 syphilis is the syphilitic tumor, which is the most destructive. The discovery of long syphilis rash should avoid sexual life, and timely medical treatment, standardized treatment under the guidance of the doctor.