There are many possibilities for overexertion leg pain, such as leg muscle strain, lactic acid stagnation, joint injury, aseptic inflammation, lumbar disc herniation and other lumbar diseases, etc. The medications used for different diseases are also different, such as ibuprofen and other painkillers, prednisone and other glucocorticosteroids, methylcobalamin and other nutritive nerve medications. 1. Leg muscle injury: overwork leads to leg muscle injury, such as mild lacerations, etc., and pain can be treated with painkillers such as ibuprofen. 2. Lactic acid stagnation: excessive lactic acid formed by anaerobic respiration of leg muscle cells due to overexertion, resulting in stagnation in the leg muscles. If the pain is severe, it can be treated with painkillers such as diclofenac sodium. 3. Joint injury: especially weight-bearing labor, the cartilage in the joints, synovial membrane and other damage, in addition to the application of ibuprofen and other painkillers, when the injury is serious, but also to give glucocorticoid drugs, such as prednisone and so on. 4. Aseptic inflammation: such as tendonitis and Achilles tendonitis, etc., can be given diclofenac sodium and other non-steroidal anti-inflammatory drugs, if necessary, can be given to the local anesthetic drugs such as lidocaine, and tretinoin and other glucocorticosteroid drugs such as closed treatment. 5. Lumbar disorders: mainly due to lumbar intervertebral disc compression of the nerve root, in addition to the application of ibuprofen and other pain relieving drugs, but also can be given to methylcobalamin and other nutritive nerve medication. Overexertion leg pain may also have other causes such as leg fatigue fracture and bone tumors, etc. It is recommended that patients go to the hospital in order to clarify the cause of the disease.