Perianal swelling with stool may be associated with perianal abscess, hemorrhoids, bacterial prostatitis and other diseases, the patient can use metronidazole, ibuprofen, ofloxacin and other drugs for treatment, the patient needs to be under the guidance of the doctor to use the drug. 1. Perianal abscess: patients with perianal abscess will have perianal swelling, patients can take oral metronidazole or ofloxacin and other drugs for treatment, patients may also need to perform incision and drainage to improve the symptoms. 2. hemorrhoids: when the hemorrhoids prolapse, there will be perianal swelling, patients can take oral ibuprofen, diclofenac and other drugs to relieve the pain, serious cases need to perform hemorrhoidectomy. 3. Bacterial prostatitis: Bacterial prostatitis may appear perineal swelling, patients can use ibuprofen to ease the pain, but also can use ofloxacin, metronidazole and other antibiotics for treatment. It is recommended that the patient go to the local hospital as soon as possible to get a clear diagnosis, to prevent delays in the condition.