There is no absolute deadline for how long liver cancer will recur after surgery, most of them will recur within 5 years after surgery and should be followed up regularly. Early stage primary liver cancer has the possibility of being cured after surgical resection and some of them may not recur. However, if there are residual tumor cells after surgery, there is a possibility of recurrence, and the recurrence rate of liver cancer can be as high as 40%~70% within 5 years after surgery. The recurrence rate can be as high as 40%~70% in 5 years after surgery. Liver cancer in middle and late stages, with high malignancy and large lesions, has a higher possibility of recurrence, and may even recur in 1~6 months after surgery. If liver transplantation is performed for hepatocellular carcinoma, the recurrence rate within 2 years after surgery accounts for about 75% of the population. In order to reduce the probability of recurrence, postoperative chemotherapy should be considered under doctor’s advice after resection of liver cancer; immunosuppressants, such as methotrexate, azathioprine, etc. should be taken after transplantation according to doctor’s advice. Regular imaging examination and liver function test should be carried out after liver cancer surgery, and once discomfort occurs or abnormality is found, timely treatment should be carried out.