Diffuse hepatocellular carcinoma refers to rice to soybean-sized cancer nodules diffusely distributed throughout the liver. Diffuse hepatocellular carcinoma is relatively rare, and it is not easy to distinguish from cirrhosis due to the distribution of cancerous nodules throughout the liver, and patients often die of liver failure. The treatment of diffuse hepatocellular carcinoma is more difficult because its lesions are scattered and often cannot be treated by surgical resection; moreover, the scattered lesions do not have a specific target area, which makes the implementation of radiotherapy difficult to a certain extent. Currently, it is often treated with anti-tumor drug Sorafenib and liver transplantation. The treatment of diffuse liver cancer patients requires doctors to formulate appropriate treatment plans according to the overall conditions of patients, so as to help patients slow down the progression of the disease and alleviate the adverse effects brought about by the disease.