Chicken skin on thighs refers to perifollicular keratosis, a chronic follicular keratotic skin disease that may be associated with autosomal dominant inheritance, vitamin A deficiency, and metabolic disorders. This disease generally does not require treatment, and can be removed using topical medications or oral medications. 1. Topical medication: 0.05% to 0.1% retinoic acid ointment, 3% to 5% salicylic acid ointment, 10% to 20% urea cream or 12% ammonium lactate lotion can be used topically to soften or dissolve keratin and improve symptoms. 2. Oral medication: If the area is large, you can take oral vitamin A, vitamin E or vitamin A acid drugs. If you want to remove the chicken skin on the thighs, you should go to the hospital and treatment, the use of the above drugs should follow the doctor’s instructions.