Most of us are still relatively new to breast genetic testing, and some of us ask what exactly is being tested for with breast genetic testing? What is the significance of breast genetic testing and what do you need to get tested for? What kind of people need to do breast genetic testing? The next I will answer these questions in detail. I. What exactly is the breast genetic test? The full range of breast genetic testing includes 9 targeted genes: AKT1, ESR1, HER2, BRCA1, BRCA2, FGFR1, FGFR2, PIK3CA, PTEN. 21 chemotherapy genes: CDA, CYP2B6, CYP2C9, CYP2D6, DPYD, DYNC2H1, ERCC1, ERCC2, GSTT1, GSTP1, MDR1, MnSOD, MPO, MTHFR, RRM1, TEKT4, TPMT, TYMS, UGT1A1, XPC, XRCC1. Probably the most familiar gene for breast cancer patients is HER2, and many patients need to use Herceptin, a targeted drug, because they are positive for HER2, a targeted gene. After reading these genes, are you a little dizzy? You don’t need to know what these genes are for, you just need to know that they are more or less related to breast cancer. The free breast genetic testing program cannot cover all genes, but mainly the BRCA1 and BRCA2 genes, which are the two genes most associated with hereditary breast cancer. What is the significance of breast genetic testing and what do I need to get tested for? Breast gene testing has great significance to the prevention and treatment of breast cancer: 1) guiding treatment, if your BRCA1/2 is positive, you can have targeted treatment; 2) predicting recurrence, generally speaking, patients with positive BRCR1/2 have higher risk of recurrence of breast cancer. 3, risk prediction and prevention guidance, if your BRCA1/2 is positive, your relatives should pay special attention and need to come to the hospital for breast physical examination regularly for early detection and prevention. The genetic sample collected this time is 4ml of blood, the time of blood sampling is to be determined, you will be notified uniformly, the location is tentatively set to our Department of General Surgery (21st floor of the Surgery Building of the First Affiliated Hospital), you can come to the blood sampling then, the information you need to bring are: ID card, your breast cancer pathology report (or discharge summary). Who needs breast genetic testing? First of all, let’s take a look at the genetic testing criteria for hereditary breast cancer according to the guidelines and norms of the Chinese Anti-Cancer Society for breast cancer diagnosis and treatment: 1. Carriers of BRCA1/BRCA2 gene mutation in their blood relatives. Patients with breast cancer who meet one or more of the following conditions: ① age at disease onset less than or equal to 45 years; ② age at disease onset less than or equal to 50 years and have a consanguineous relative who is also a breast cancer patient with age at disease onset less than or equal to 50 years and/or a patient with ovarian epithelial cancer/fallopian tube cancer/primary peritoneal cancer of any age; ③ having two primary breast cancers with age at first disease onset less than or equal to (3) Patients with 2 primary breast cancers and the age of first onset is less than or equal to 50 years; (4) Patients with 2 or more blood relatives with breast cancer and/or ovarian epithelial cancer, fallopian tube cancer or primary peritoneal cancer at the same time, regardless of the age of onset; (5) Male blood relatives with breast cancer; (6) Combined history of ovarian epithelial cancer, fallopian tube cancer or primary peritoneal cancer. 3.Patients with ovarian epithelial cancer, fallopian tube cancer and primary peritoneal cancer. 4.Male breast cancer patients. 5.Patients with the following family history in general: ①Any of the above conditions among the first- or second-degree relatives who are related by blood; ②Two or more breast cancer patients among the third-degree relatives who are related by blood (at least one with age of onset less than or equal to 50 years) and/or ovarian epithelial cancer/fallopian tube cancer/primary peritoneal cancer patients.