Elevated bilirubin in patients treated with febuxostat may be due to adverse drug reactions to febuxostat or due to hemolysis and biliary obstruction. 1. Febuxostat is a uric acid-lowering drug, and its common adverse drug reactions include abnormal liver function, nausea, skin rash and liver damage, and elevated bilirubin. Therefore, the elevation of bilirubin in patients treated with febuxostat may be due to the adverse drug reaction of abnormal liver function of the drug. 2. In addition, elevated bilirubin may also be caused by hemolysis, biliary obstruction, etc. Therefore, patients taking Febuxostat need to further improve the liver function and other auxiliary tests to clarify the cause of elevated bilirubin. It is recommended that patients with elevated bilirubin on febuxostat should go to the rheumatology department of a regular hospital for further treatment, so as to identify the cause of the elevated bilirubin and then give targeted treatment.