Lung squamous carcinoma refers to squamous cell carcinoma of the lung, and this disease can be treated with targeted therapy without chemotherapy with drugs such as afatinib or anilotinib, as well as radiation therapy and immunotherapy in the advanced stage of the disease. Lung squamous cell carcinoma is a pathological type of non-small cell lung cancer. Usually, chemotherapy is the main treatment for advanced squamous cell carcinoma of the lung, if patients do not take chemotherapy, they can also take drugs for targeted therapy under the guidance of doctors, and commonly used drugs include afatinib and anilotinib. Targeted therapy can selectively inhibit tumor cells to a certain extent, stabilize the disease and prolong the survival period of patients. In addition to targeted therapy, patients can also choose radiotherapy, palliative radiotherapy is generally considered, followed by immunotherapy, commonly used drugs such as nabulizumab and pabolizumab. To summarize, patients with squamous cell carcinoma need to go to the hospital in time, strengthen the daily life management, cooperate with doctors for active treatment, improve the quality of life, and alleviate the clinical symptoms, so as not to delay the condition.