SMD1 antibody positivity is severe. SMD1 antibody is an anti-non-histone antibody with high specificity for the diagnosis of SLE and is a serum marker antibody for SLE. Therefore, SMD1 antibody positivity should be alerted to the presence of SLE. SLE can cause systemic inflammatory reaction and vascular abnormality, which leads to systemic multi-organ system damage, causing fever, skin erythema, pericardial effusion, nephritis, pericarditis, pulmonary fibrosis, loss of appetite, vomiting, anemia, lupus headache, and other symptoms, which is harmful and has a greater impact on patients. For patients with positive SMD1 antibody results without clinical symptoms, false positive test results cannot be ruled out and the SMD1 antibody results should be reviewed. Therefore, patients with positive SMD1 antibody results should go to the hospital in time and undergo regular treatment with the help of a doctor.