Gastroesophageal reflux disease (GERD) is a disease in which the contents of the stomach and duodenum reflux into the esophagus, resulting in heartburn, acid reflux, belching, burning pain behind the sternum, a feeling of blockage or obstruction in the pharynx, or even unfavorable swallowing or food spillage, and can lead to esophagitis and damage to tissues other than the esophagus, such as the pharynx and trachea, and is GERD can be divided into three types: reflux esophagitis (RE), non-erosive reflux disease (NERD) and Barrett’s esophagus, with non-erosive reflux disease accounting for more than 80% of the cases. The main clinical symptoms: acid reflux (severe acid vomiting), regurgitation, chest pain (retrosternal pain), back pain, heartburn, chronic pharyngitis, etc. A significant number of patients will make the appearance of asthma, cough and other manifestations. Diagnosis: Non-erosive reflux disease is mainly diagnosed by esophageal manometry and 24-hour esophageal pH measurement, while reflux esophagitis and Barrett’s esophagus are diagnosed by gastroscopy. The misdiagnosis rate of this disease is high because most patients present with chronic superficial gastritis on gastroscopy; most hospitals in China do not have esophageal manometry and 24-hour esophageal pH measurement equipment to confirm the diagnosis; this disease is often confused with chronic gastritis and coronary angina. Epidemiology: In a survey on GERD conducted in Xi’an, China, the incidence of major symptoms of GER (MS GER), GERD, abnormal gastroesophageal reflux (AG-ER) and RE in adults in Xi’an was 16.98%, 3.87%, 3.49% and 2.4%, respectively; in a randomized whole-group survey on reflux disease conducted in southern China, 3338 patients were found to have GERD. In a randomized whole-group sample survey on reflux disease conducted in southern China, the incidence of heartburn and/or acid reflux was found to be 6.2% among 3338 respondents at least once a week, which is much lower than that in western countries. The epidemiological survey of GERD conducted in Beijing and Shanghai predicted that the prevalence of GERD was 5.77%, and the incidence of GER-related symptoms in Beijing was 1O% and 7.68% in Shanghai. The study by Xiong Lishou et al. showed that the prevalence of GERD in the community population of Guangdong Province was 2.3%, which was significantly lower than that in western countries and also lower than that in Beijing and Shanghai. Zhang Hong et al. showed that the prevalence rate of 7.2 8% in the outpatient internal medicine population in Zhejiang Province was higher than that in Guangdong Province and slightly higher than that in Shanghai and Beijing. A nationwide random telephone survey conducted in the United States found that the prevalence of GERD was 14%, and the prevalence of nocturnal GERD was 10%. a telephone survey conducted in Switzerland in 2004 found that the prevalence of reflux disease among adults was 17.6%, similar to the prevalence in other European and American countries. The development of GERD is a multifactorial process that involves the dysfunction of two mechanisms: prevention of excessive GERD and rapid elimination of harmful substances from the esophagus; low LES pressure, weakened peri-LES tissues, transient relaxation of the LES, impact of esophageal hiatal hernia on the anti-reflux barrier, reduced esophageal contouring ability, and HP infection. GERD can occur. Treatment: At present, we mainly rely on acid suppressants, motivational drugs and traditional Chinese medicine. The biofeedback program studied by Prof. Meiyun Ke of Peking Union Medical College Hospital is also effective and can reduce the amount of drugs used. However, the drug treatment period is long and the cost is large. The disease still cannot be completely cured.