Tetanus immunoglobulin can replace tetanus toxoid because prevention of tetanus is much more important than treatment in clinical practice. Tetanus toxoid mainly stimulates the body’s active immunity, so that the body produces its own tetanus immunoglobulin, thus avoiding tetanus attacks caused by tetanus infection, and playing a preventive role in tetanus. Tetanus toxoid need to do skin test to avoid allergy, for tetanus toxoid allergic patients, or more than 24 hours after the injury, has been unsuitable to use tetanus toxoid to stimulate the body’s active immunity, you can use tetanus immunoglobulin as a substitute, so as to avoid tetanus infection caused by tetanus attack. However, since tetanus endotoxin is cheaper and tetanus immunoglobulin is more expensive, tetanus toxoid is usually preferred in clinical practice.