Sacroiliac arthritis B27 positive indicates a rheumatologic immune system disorder and treatment includes general therapy, medications, physical therapy, and surgery. Sacroiliac arthritis is an inflammatory lesion that occurs in the sacroiliac joints, usually secondary to other diseases. The main clinical manifestations are low back pain, hip pain and morning stiffness. Laboratory examination of human leukocyte antigen B27, C-reactive protein and other indicators can be used to clarify the etiology and differential diagnosis. 1. General treatment: including regular diet, work and rest, avoid prolonged sitting position, appropriate exercise, avoid cold, weight-bearing triggers. 2. Drug treatment: non-steroidal anti-inflammatory drugs such as indomethacin and loxoprofen can be applied to relieve pain and morning stiffness. If accompanied by muscle spasm, muscle relaxants such as chlorzoxazone and tizanidine can be used to relieve the pain. 3. Physiotherapy: Heat therapy and ultrasound can be used to relieve pain and muscle spasm and prevent further development of the disease. 4. Surgical treatment: For patients with poor results of non-surgical treatment, surgical treatment can be used to relieve pain and improve joint function. Patients with B27 positive sacroiliitis should undergo standardized treatment under the guidance of a doctor. All of the above medications should be used under the guidance of a doctor to avoid self-medication.