The clinical manifestations of Mycoplasma urealyticum are still mainly urethritis. Mycoplasma urealyticum is a special pathogen, neither bacteria nor virus, mainly hosted in the human genital tract and urethra, etc. It can be carried by normal people but does not cause disease, if it develops, the clinical manifestations may include symptoms of urinary tract irritation. Mycoplasma urealyticum is one of the pathogens that cause non-gonococcal urethritis, but 20-50% of the population does not have significant clinical symptoms. Symptoms can occur when the body is immunocompromised. For male patients, the concomitant symptoms are mainly urinary discomfort with increased urethral discharge, which is mostly plasma or plasma-purulent, thinner and in small amounts. For female patients, it is often accompanied by painful urination, frequent urination, increased leucorrhea, yellowish or bloody, bleeding during non-menstrual periods or after sexual intercourse, cervical congestion, edema, and effects on the fetus during pregnancy, so premarital and preconception testing is necessary. In summary, Mycoplasma solani can be present in the urinary tract without developing. If it does, it can cause symptoms associated with urinary tract infections and requires prompt treatment.