Toothpaste is used as a daily household product to clean your teeth and it is not known to cause fever. No matter where you apply it on your body, it will not cause a fever. A fever is actually an immune response of the body, an inflammatory response of the immune system to some foreign body, or pathogenic microorganism from outside. When there is a fever can activate the body’s immune system, thus causing the removal of external microorganisms, especially for foreign bodies, bacteria, viruses have a very good killing effect, so in the cold or bronchitis, pharyngitis, gastroenteritis will appear fever this situation. In addition to infectious diseases, other non-infectious diseases can also cause fever, such as rheumatoid arthritis, blood diseases, tumors, and so on. Therefore, when identifying fever, it is important to note that many of them are not necessarily infections, and many non-infectious diseases can also cause fever, which is worth special attention.