The main ingredients of toothpaste are rubbing agents, washing foam agents, adhesives, spices and moisture. Among the fragrances, many toothpastes contain mint and eucalyptus. Mint has an inhibitory and numbing effect on peripheral nerves, and when applied to the glans, it can feel a cool sensation and can delay ejaculation, and many male patients apply toothpaste to the glans to prolong ejaculation. In fact, this has certain risks and side effects. In addition to numbing, mint is also irritating and repeated application can lead to glans congestion. Toothpaste also has an abrasive component, and repeated application can cause minor abrasions to the glans. It can also irritate the female vagina, causing discomfort to the female partner. Some of the chemical components in toothpaste may affect male semen, which can lead to semen abnormalities causing male infertility, so toothpaste can be applied appropriately and not for a long time.