Large swelling after insect bites is considered to be related to insect bite dermatitis, which can be relieved by oral medication, topical medication, and daily care. 1. Oral medication: Bug bites can cause heterogeneous proteins in the saliva to enter the body, triggering an allergic reaction that leads to swelling. Antihistamine medication, such as loratadine tablets and levocetirizine hydrochloride tablets, can be taken to reduce the exudation of local blood vessels and alleviate the symptoms of swelling. 2. Topical medication: After being bitten by insects, the local area will also be accompanied by itching symptoms, you can locally apply glycerine lotion, compound menthol ointment, hydrocortisone butyrate ointment and other drugs, which can achieve the effect of anti-allergy and anti-itch. 3. Daily care: do a good job of local skin care, you can use mild non-irritating soap or shower gel to clean the skin, avoid excessive scratching, in order to avoid triggering symptoms of infection. If the patient’s large swelling symptoms persist without improvement, should be timely to the hospital for treatment, the above drugs should be used in accordance with medical advice.