Male infertility is the result of a variety of diseases and/or factors, usually divided into pre-testicular, testicular and post-testicular factors depending on the reproductive link affected, but still up to 60%-75% of patients cannot find the cause (clinically known as idiopathic male infertility). I. Pre-testicular factors Usually endocrine in origin, the patient’s fertility is impaired secondary to a hormonal imbalance in the body. 1. Thalamic disorders 2. Pituitary disorders 3. Endogenous or exogenous hormonal abnormalities II. Testicular factors 1. Congenital abnormalities 2. Gonadotoxins. There are common factors such as radiation, drugs, food, living and working environment. 3, systemic diseases. Such as renal failure, liver cirrhosis, etc. 4, infection (testicular inflammation) 5, testicular trauma and surgery 6, vascular factors (varicocele) 7, testicular torsion 8, immunological factors III, post-testicular factors 1, vas deferens obstruction (obstructive azoospermia is 7%-10% in male infertility patients). 2, sperm function or motility disorders. 3, immune infertility 2%-10% of infertility is related to immune factors, and anti-sperm antibodies are the main cause. Common causes include testicular trauma, torsion, biopsy, infection or vas deferens obstruction, post-anastomosis surgery, etc. 4, Infection 8%-35% of infertility is related to male reproductive tract infection. 5, sexual intercourse or ejaculatory dysfunction. Idiopathic factors: Idiopathic infertility refers to male infertility who cannot find a clear cause, and the link affecting reproduction may involve one or more links in the pre-testicular, testicular, or post-testicular. The current tendency is to correlate with genetic or environmental factors, among others.