Multiple anal lymph node enlargement after liver cancer surgery, if it is metastasis of liver cancer, it indicates advanced liver cancer, and the five-year survival rate is less than 5%; if it is not metastasis, the survival period is related to the stage of liver cancer. Liver cancer lymph node metastasis indicates that the disease has entered advanced stage, and the general five-year survival rate is less than 5%. Multiple lymph node enlargement in anus may not be cancer metastasis, and the survival period can be greatly prolonged in case of complete resection of liver cancer. Its survival period is related to the stage of liver cancer. In case of early liver cancer, the five-year survival rate can be up to 70%, while in late stage, it is less than 5%. Multiple anal lymph node enlargement after liver cancer surgery should go to the hospital in time, improve relevant examination to clarify the cause, and carry out standardized treatment under doctor’s guidance.