From the perspective of Chinese medicine, the most common factor is internal deficiency, often due to kidney deficiency, qi deficiency, blood deficiency and yin deficiency, resulting in the clinical condition of a cold body. From the perspective of Western medicine, the most common factors are endocrine diseases, such as hypothyroidism and adrenal cortical insufficiency, which reduce the effective heat production in the body and lead to the clinical symptoms of body coldness. Coldness is also associated with a slowing of the endocrine metabolic rate, such as an imbalance of the endocrine metabolic rate or a low basal metabolic rate, which can also occur. Finally, it is also associated with inflammatory factors mediated by infection, which can occur when the body is infected by bacteria, viruses or pathogenic microorganisms.