When you take hormones for kidney disease, it has to take about 2 weeks to take effect in the faster case, and in the slower case, it may take about 3 months. Nephropathy mainly refers to nephrotic syndrome, which is a disease related to immunity, so it needs to apply hormone to treat. If the patient is sensitive to hormones, such as children, the hormones may take effect about 2 weeks after application. At this time, the urine protein may turn negative, and the urine volume also appears to increase significantly. If the patient belongs to the type that is not very sensitive to hormones, some patients may have a decrease in urine protein about 3 months after the application of hormones. This situation is mainly seen in membranous nephropathy. Therefore, when hormones are applied to treat nephrotic syndrome in clinic, it is usually observed for 2-3 months. If after 3 months, there is still no reduction of urinary protein, then it is necessary to combine with immunosuppressants to treat together, the more commonly used immunosuppressants are cyclophosphamide and tacrolimus.