The difference between coffee spots and neurofibroma is different etiology, different symptoms, different prognosis and so on. 1. Different etiology: Coffee spot, also known as coffee milk spot, is a common hyperpigmentation skin disease and a manifestation of many systemic diseases, such as neurofibroma, tuberous sclerosis pygmy, polycythemia vera, and ataxia telangiectasia, etc. Neurofibroma is an autosomal dominant hereditary disease. Neurofibroma belongs to autosomal dominant hereditary disease, mainly caused by gene mutation, such as patients with long-term exposure to harmful chemicals, radiation and so on, will induce the emergence of the disease. 2. Symptoms are different: coffee spots will appear in all parts of the skin, will appear at birth or after birth, is a light brown spot, brown to dark brown, size varies, clear boundary, smooth surface, will not fade away. Neurofibroma can involve all systems of the body, different types, symptoms are different, mainly manifested as armpit freckles, milk coffee spots and associated tumor compression. 3. Different prognosis: cafe-au-lait spots generally do not need treatment and will not affect the health of the body, while some cafe-au-lait spots have certain genetic tendency. Most patients with neurofibroma have slow development, sometimes static, but a few patients will have malignant changes. In addition, there is also a certain difference in the treatment, it is recommended that the patients go to the regular hospital in time, under the diagnosis of the doctor, according to the specific performance of the patient’s condition, to take targeted treatment, and pay attention to the regular checkups in life.