What are the risks of endometrial thickening? Endometrial thickening can affect a woman’s ability to get pregnant because the ovarian cycle produces eggs and secretes estrogen and progesterone, resulting in enhanced blood flow to the endometrium, leading to thickening of the endometrium, and the hyperplastic endometrium may affect the union of sperm and egg. In severe cases, endometrial thickening can also cause a woman to bleed heavily and lead to shock, as the most common symptom of endometrial thickening is vaginal bleeding, but each person’s bleeding varies. If the bleeding is excessive, it can cause a woman to go into shock or lead to hemorrhagic anemia. Endometrial thickening can also cause endocrine disorders in women, which can affect their skin and appearance. Thickening of the endometrium is related to the hormone levels in a woman’s body. Thickening of the endometrium indicates endocrine disorders in women, which can lead to blemishes and a dull complexion.