Children with herpes at the corners of the mouth mostly belong to herpes simplex type I virus infection, causing a viral infection disease. In clinical treatment, oral acyclovir tablets are needed, usually for not less than 5 days, together with the application of Bibaique capsules with clearing fire and detoxification, to enhance detoxification and blood cooling treatment. Topical medications can be chosen from penciclovir ointment application and also neomycin ointment treatment. It is also important to strengthen local maintenance treatment and closely observe the occurrence of herpes infectious diseases such as herpetic pharyngitis and herpetic tonsillitis to avoid local manifestations of high fever and other systems due to viral infection.