Indirect bilirubin is three times higher than the normal value, and glutamic oxaloacetic transaminase is normal, which may be related to hereditary erythrocytosis, autoimmune hemolytic anemia, liver failure and other causes. Splenectomy, glucocorticoids, antiviral drugs, etc. can be prescribed to treat the cause of the disease. 1. Hereditary erythrocytosis: it is congenital hemolytic anemia. The clinical manifestations of anemia, intermittent jaundice and splenomegaly may occur since childhood. Since there is no damage to the liver cells, there is a normal alanine aminotransferase and elevated indirect bilirubin. Blood transfusion and splenectomy can be used for treatment. 2. Autoimmune hemolytic anemia: it belongs to acquired hemolytic anemia. It is a hemolytic anemia in which red blood cells are destroyed due to abnormal immune regulation. Indirect bilirubin may be elevated while glutamine transaminase is normal. Glucocorticoids, splenectomy, immunosuppressants, etc. can be used for treatment. 3. Liver failure: In severe hepatitis liver failure, due to severe necrosis of hepatocytes, bilirubin will be elevated while aminotransferase will be decreased, which is the phenomenon of “separation of enzyme and bile”. At this time, it is necessary to treat the cause of hepatitis with antiviral and hepatoprotective treatment, and liver transplantation if necessary. There are many other causes of elevated indirect bilirubin and normal AST, it is recommended to consult a doctor in time to identify the cause of the disease and then carry out the treatment to avoid delaying the disease.