Long-term use of glucocorticoids can cause full-moon face, buffalo back, centripetal obesity, etc., and can cause abnormal glucose metabolism. In the process of taking hormones, the following points should be done to avoid gaining weight: First, control the diet. Hormones can promote glucose absorption, raise blood sugar, cause protein decomposition and promote fat synthesis, so in the process of taking hormones, protein intake should be increased appropriately, starchy food intake should be reduced, and the total calories per day should be limited. Second, increase the amount of exercise, exercise can increase calorie consumption to avoid fat accumulation and body fat. Moreover, exercise can improve insulin sensitivity and counteract some side effects of hormones. Third, timely hormone reduction in the process of taking hormones, taking hormones for a short time will not necessarily cause weight gain. Fourth, blood sugar, blood pressure and other indicators should be regularly monitored during the process of taking hormones.